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School Department
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Author:
Ma Lan
dafabet best online betting websiteSource:
No.1 High School Affiliated to China Normal University
Visits:
2012-09-05
Shen Xiaohua (alumnus of the class of 1992)
Female，Graduated from the No. 1 High School Affiliated to Central China Normal University in 1992，Received a bachelor’s degree from Nankai University in 1996；Graduated from the Department of Biochemistry, University of Michigan Medical School in 2003 and received a PhD；Engaged in postdoctoral research at the University of Michigan Medical School and Harvard Medical School，2009 Lecturer at Harvard Medical School，Returned to China in 2010 to work as a professor at Tsinghua University School of Medicine，2011，Science with "Focus on China's Scientific Research: Big Countries，Big Science》Follow Shen Xiaohua。Now，She became the chief scientist of the 973 project in 2012，The project name is "Epigenetic regulatory network for directed differentiation of pluripotent stem cells"。
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1. Overview of scientific research
Using interdisciplinary biological methods，includes mouse genetics、Molecular and Cellular Biology, Genome and Biomics, etc.Systems BiologyTechnology，Studying epigenetic mechanisms in stem cell differentiation，Role in cell function and fate determination。
Research direction: stem cell biology and epigenetics。Embryonic stem cells have the multi-directional differentiation potential to form all types of cells in human and animal individuals，And can continuously update itself。These two characteristics of embryonic stem cells make them not only important in biological research，And it is used for cell replacement therapy，has immeasurable medical uses and prospects。Higher organisms are composed of many types of cells。They have the same genetic material，But different epigenetic information。The process dafabet best online casinoof organism development is the process of establishing a variety of epigenetic information in different cells。The most important research questions in the life sciences include analyzing the unique epigenetic information of various types of cells，And discover how they are built，How to selectively affect the expression of some genes in different cells，Thus determining cell function and fate。Mutations in epigenetic mechanisms are often closely linked to human diseases。
Mainly using interdisciplinary biological methods，includes mouse genetics，Molecular and cell biology and systems biology technologies such as genome and genomics，Studying epigenetic mechanisms in stem cell differentiation，Role in cell function and fate determination。The research results will provide an important framework for understanding the epigenetic mechanism in regulating gene expression at the systemic and molecular levels，Stem cell differentiation、Role in development and disease，Promote the clinical realization of stem cell therapy，And provide novel drug clues to treat cancer，Provides an important design blueprint for the construction of future artificial cells。
2. Main honors and academic appointments
Bayer Outstanding Young Researcher，Tsinghua University， 2010
Claudia Adams BarrCancer Research Award, United States, 2009
Boston Children’s Hospital Stem Cell Day Best Report Award，Harvard University, USA，2008
Adam and Mary J. Chrisman Award Award, University of Michigan, USA, 2002
973Chief Project Scientist，The project name is "Epigenetic regulatory network for directed differentiation of pluripotent stem cells"， 2012
3. Representative works
Wilson BG, Wang X, Shen X, McKenna ES, Lemieux ME, Cho Y, Koellhoffer EC, Pomeroy SL, Orkin SH, Roberts CWM. Epigenetic antagonism between Polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell2010; 18(4):316-28.
Shen X, Kim W, Fujiwara Y, Simon MD, Liu Y, Mysliwiec MR, Yuan G, Lee Y, Orkin SH. Jumonji modulates Polycomb activity and self-renewal versus differentiation of stem cells. Cell2009; 139(7): 1303-1314.
Shen X, Orkin SH. Glimpses of the epigenetic landscape. Cell Stem Cell 2009; 4(1): 1-2.
dafabet online sports betting appShen X, Liu Y, Hsu Y, Fujiwara Y, Kim J, Mao X, Yuan G, and Orkin SH. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell 2008; 32(4):491-502.
Shen X, Ellis RE, Lee K, Liu C, Yang K, Solomon A, Yoshida H, Morimoto R, Kurnit DM, Mori K, and Kaufman RJ. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell2001;107: 893-903.
In 2011，&ldquo hosted by alumnus Shen Xiaohua in Bio Valley;2011 Stem Cell Technology Clinical Translation Application Lecture and Training”gave a wonderful speech entitled "Epigenetic Regulation of Stem Cell Pluripotency"，Widely praised by the delegates。
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Copyright © The First Affiliated Middle School of Central China Normal University. All Rights Reserved
Principal’s email: hsyxb01@163.com
Postcode: 430223
School address: No. 1, Tangxun Hubei Road, Donghu High-tech Development Zone, Wuhan City, Hubei Province
Hubei Public Network Security No. 42018502002265
Copyright © The First Affiliated Middle School of Central China Normal University. All Rights Reserved